Footnotes

• Handling editor Iskander Chaudhry.

• Contributors SDM conceived of the project and critically reviewed the manuscript. VC-LC wrote the manuscript. CLT provided the slide and provided input on the histopathology component. Y-LC critically reviewed the manuscript and edited the clinical component.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent Obtained.

• Provenance and peer review Commissioned; internally peer reviewed.