Footnotes

• Handling editor Tony Mazzulli.

• Contributors JM had the concept of the work, codesigned the experiments, analysed the data and wrote the manuscript. HW performed the laboratory investigations, analysed the data and approved the final version of the manuscript. JS and JMC were involved in laboratory investigations and corrected and approved the final version of the manuscript. BS, DD and ME codesigned the experiments with JM and corrected and approved the final version of the manuscript.

• Competing interests None declared.

• Patient consent for publication Not required.

• Provenance and peer review Not commissioned; externally peer reviewed.