Footnotes

• Handling editor Runjan Chetty.

• Contributors MR designed the study, analysed the data, drafted the paper. CDC analysed some digital patients’ data, drafted the paper. GP designed the study, analysed patients’ the data, drafted the paper. EM analysed some digital patients’ data, drafted the paper. MM analysed the data, drafted the paper. GR analysed patients’ the data. VL, MO, VP and LB analysed some digital patients’ data. SV drafted the paper. TF drafted the paper and revise it, approved the submitted version of the paper.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Provenance and peer review Not commissioned; internally peer reviewed.