Footnotes

• Handling editor David Creytens.

• Contributors LVF and TS conceptualised the study. JG, RM, LJT, MK and ASP provided clinical care of the patient and clinical data. TS, SCK and RER performed histopathological evaluation and provided histopathology data. LVF and ZS analysed the molecular data. LVF interpreted the molecular data and wrote the original draft. TS and ZRA assembled the figures. All authors reviewed the writing and edited the manuscript.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.