PT  - JOURNAL ARTICLE
AU  - King, P
AU  - Craft, A W
AU  - Malcolm, A J
TI  - p53 expression in three separate tumours from a patient with Li-Fraumeni's syndrome.
AID  - 10.1136/jcp.46.7.676
DP  - 1993 Jul 01
TA  - Journal of Clinical Pathology
PG  - 676--677
VI  - 46
IP  - 7
4099  - http://jcp.bmj.com/content/46/7/676.short
4100  - http://jcp.bmj.com/content/46/7/676.full
SO  - J Clin Pathol1993 Jul 01; 46
AB  - The Li-Fraumeni cancer syndrome is a rare autosomal dominant syndrome, characterised by the occurrence of diverse mesenchymal and epithelial neoplasms at multiple sites. It has recently been shown that some of these individuals have a germ line mutation of the p53 tumour suppressor gene. The case of one member of such a family who has now developed three separate primary malignant tumours is reported. All three tumours expressed mutant p53 protein.