PT  - JOURNAL ARTICLE
AU  - Adhikary, A K
AU  - Inada, T
AU  - Numaga, J
AU  - Suzuki, E
AU  - Ushijima, H
AU  - Banik, U
AU  - Mukouyama, A
AU  - Matsuno, S
AU  - Okabe, N
TI  - Characterisation of hexon and fibre genes of a novel strain of adenovirus involved in epidemic keratoconjunctivitis
AID  - 10.1136/jcp.57.1.95
DP  - 2004 Jan 01
TA  - Journal of Clinical Pathology
PG  - 95--97
VI  - 57
IP  - 1
4099  - http://jcp.bmj.com/content/57/1/95.short
4100  - http://jcp.bmj.com/content/57/1/95.full
SO  - J Clin Pathol2004 Jan 01; 57
AB  - Aims: To characterise a novel strain (M86) of adenovirus (Ad) involved in epidemic keratoconjunctivitis (EKC). Methods/Results: The virus strain was neutralised by antisera to both Ad35 and Ad11. Restriction endonuclease analysis of genomic DNA showed 98% and 88% homology with Ad11 and Ad35, respectively. The deduced amino acid sequence of the hypervariable regions of (HVRs) of the hexon gene showed a higher homology with Ad35 (94.4%) than with Ad11 (83.7%). However, it was 100% homologous to Ad35 in HVRs 1, 2, 3, and 6 and to Ad11 in HVRs 4 and 6. In the fibre knob, the isolate was more homologous to Ad11 (99.4%) than to Ad35 (29.1%). Conclusion: This novel strain of adenovirus showed similarities with both Ad11 and Ad35. The isolation of a novel strain like Ad35+11 is important because of its association with EKC.