PT  - JOURNAL ARTICLE
AU  - Cook, N
AU  - Brais, R
AU  - Qian, W
AU  - Chan Wah Hak, C
AU  - Corrie, P G
TI  - Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma
AID  - 10.1136/jclinpath-2014-202521
DP  - 2015 Apr 01
TA  - Journal of Clinical Pathology
PG  - 309--313
VI  - 68
IP  - 4
4099  - http://jcp.bmj.com/content/68/4/309.short
4100  - http://jcp.bmj.com/content/68/4/309.full
SO  - J Clin Pathol2015 Apr 01; 68
AB  - Background Endothelin-1 (ET-1) acting through endothelin A and B receptors (ETAR and ETBR) has been implicated in the development of cancer. The endothelin axis has not previously been characterised in human pancreatic adenocarcinoma (PAC).Methods Expression of ET-1, ETAR, ETBR, vascular endothelial growth factor and microvessel density (MVD) was determined by immunohistochemistry in 45 surgically resected human PACs and 15 non-cancer human pancreas samples.Results PAC had the highest staining intensity for ET-1 and ETBR: 38% PAC samples scored 2+ or more compared with 7% non-cancer sample in ET-1; 58% PAC samples scored 2+ compared with 0% non-cancer samples in ETBR. MVD was significantly lower in PAC compared with non-cancer tissue (p<0.0001).Conclusions PAC was characterised by greater expression of ET-1 and ETBR compared with normal pancreas.