RT Journal Article
SR Electronic
T1 Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 309
OP 313
DO 10.1136/jclinpath-2014-202521
VO 68
IS 4
A1 Cook, N
A1 Brais, R
A1 Qian, W
A1 Chan Wah Hak, C
A1 Corrie, P G
YR 2015
UL http://jcp.bmj.com/content/68/4/309.abstract
AB Background Endothelin-1 (ET-1) acting through endothelin A and B receptors (ETAR and ETBR) has been implicated in the development of cancer. The endothelin axis has not previously been characterised in human pancreatic adenocarcinoma (PAC).Methods Expression of ET-1, ETAR, ETBR, vascular endothelial growth factor and microvessel density (MVD) was determined by immunohistochemistry in 45 surgically resected human PACs and 15 non-cancer human pancreas samples.Results PAC had the highest staining intensity for ET-1 and ETBR: 38% PAC samples scored 2+ or more compared with 7% non-cancer sample in ET-1; 58% PAC samples scored 2+ compared with 0% non-cancer samples in ETBR. MVD was significantly lower in PAC compared with non-cancer tissue (p<0.0001).Conclusions PAC was characterised by greater expression of ET-1 and ETBR compared with normal pancreas.